BIOLOGICAL ACTIVITY 7-CHLOROSUBSTITUTED OF CHINOLINE (REVIEW)

Abstract

In recent years, much attention has been paid specifically to the modification of natural compounds in order to obtain more effective biologically active substances, which are endowed with the necessary complex of properties. Nitrogen-containing quinoline derivatives (quinoline, Q) is one of the promising directions for the search for biologically active substances with antimalarial action based on quinoline alkaloids (quinine and its analogs). They are also endowed with antimicrobial activity and occupy an important place in the modern arsenal of antibacterial chemotherapeutic agents. Quinoline preparations act mainly on the gram-negative
flora, and also have antiprotozoal action (dysentery amoeba, giardia, trichomonas, etc.). The data on the biological activity of quinoline halogens are analyzed. They have been found to be promising biologically active substances with various types of biological action, such as: antimalarial, antibacterial, antioxidant and other signs of biological action. There are also compounds with anti-cancer and immunomodulatory properties, promising structures for the treatment of herpes virus. The inhibition of antimicrobial activity of gram-positive and gramnegative microorganisms was established. Among quinoline derivatives, substances have been found that demonstrate not only bacteriostatic and fungistatic activity but also analgesic.
Quinoline derivatives with halogen atoms demonstrate the considerable potential of antimalarial, antimicrobial and antiparasitic drugs. The introduction of chlorine or bromine atoms into the structure of the 8-hydroxyquinoline molecule led to a significant increase in their biodiversity, and fluorine – for quinolones-4 – generally created the preconditions for the development of a number of synthetic antibiotics. A number of antimicrobials have been developed based on quinolone derivatives, in particular synthetic antibiotics – fluoroquinolones.In addition, quinoline derivatives are used as pesticides, veterinary drugs, dyes, chemical reagents and others.