РЕАКЦІЯ МАСТОЦИТІВ НА ПЕРФУЗІЮ СЕРЦЯ РОЗЧИНОМ ІНТЕРФЕРОНУ

  • С. П. Бесчасний
  • М. М. Найдьонов
  • О. М. Гасюк

Abstract

Beschasnyi S.P., Naydenov M.N. Gasiuk E.N. REACTION OF MASTOCYTES DURING PERFUSION OF HEART INTERFERON SOLUTION Keywords: recombinant interferon-α2b, β-blocker propranolol, the perfusion of the heart. In model experiments on isolated mouse hearts showed that the transmittance of perfusion with Krebs solution preparation of the recombinant interferon-α2b leads to a "fast" effect of activation of resident mast cells, which is shown enlarged, increasing the intracellular amount of basophilic granules with an active content. However, adding to the perfusion solution of the non-selective β- blocker propranolol results in a leveling of the activating effect of interferon on mast cells, reducing their pro-inflammatory activity, which is activated by ischemia and in conditions of high concentrations of interferon action.

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2017-09-12
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