ФІЗИЧНА ПРАЦЕЗДАТНІСТЬ В УМОВАХ ВПЛИВУ ЕРИТРОПОЕЗ-СТИМУЛЮЮЧОГО ФАКТОРУ
Анотація
This article provides information about studying of physical disability of white laboratory mice in long-term injection of different doses of recombinant erythropoietin. It was found that a one injection of erythropoietin in concentrations 0.65 IU, 3.5 IU and 6.5 IU leads to minor increases of physical performance parameters, the most productive changes were marked after the second injection, as evidenced by the double increase indicators of activity and endurance. In the third injection is overdose of hormone and as a result - a sharp decline of options. In the control group there is the gradual increase of physical performance, we think that it is the result of regular training. Injection of hormone in the end of study didn’t give reliable results. A possible explanation for this result may be phenomenon of body’s habituation to a high multiple of injections of erythropoietin.Посилання
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13. Marzo F. Erythropoietin in heart and vessels: focus on transcription and signalling pathways / F. Marzo, A. Lavorgna, G. Coluzzi, E. Santucci, F. Tarantino, T. Rio, E. Conti, C. Autore, L. Agati and F.Andreotti // Journal of Thrombosis and Thrombolysis. - 04/2008.- 26(3). – Р. 183-187.
14. Miskowiak K. Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration / K. Miskowiak, B. Inkster, S. Selvaraj, R. Wise, G. Goodwin, C. Harmer // Neuropsychopharmacology. – 2008. - № 33. – Р. 611-618.
15. Ninot G. Effects of recombinant human erythropoietin injections on physical self in endurance athletes / G. Ninot, P. Connes, C. Caillaud // J Sports Sci. – 2006. - №24. – Р. 383-391.
16. Paschos N. The Role of Erythropoietin as an Inhibitor of Tissue Ischemia / Nikolaos Paschos, Marios G. Lykissas and Alexandros E. Beris // International Journal of Biological Sciences. - 2008. - № 4(3). – Р. 161-168.
17. Porsolt R. D. Depression: а new animal model sensitive to antidepressant treatments / R. D. Porsolt, M. Le Pinchon, M. Jalfre // Nature. - 1977. - № 5604. - P. 730–732.
18. Ricci G. Effects of a mixed physical activity (biathlon) on haematologic parameters, red cell 2,3-DPG and creatine, serum erythropoietin, urinary enzymes and microalbumin / G. Ricci, M. Masotti, E. De Paoli, M. Vedovato, G. Zanotti // Eur. J. Haematol. – 1990. - №45. – Р. 178-179.
19. Schmidt W. Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level / W. Schmidt, K. Eckardt, A. Hilgendorf, S. Strauch, C. Bauer // Int. J. Sports. Med. – 1991. - №12. – Р. 457-461.
20. Schobersberger W. Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude / W. Schobersberger, P. Hobisch-Hagen, D. Fries, F. Wiedermann, J. Rieder-Scharinger, et al. // Immunobiology. – 2000. - №201. – Р. 611-620.
21. Schwandt H.J. Influence of prolonged physical exercise on the erythropoietin concentration in blood / H.J. Schwandt, B. Heyduck, H.C. Gunga, L. Rocker // J. Appl. Physiol. Occup. Physiol. - 1991. - №63. – Р. 463-466.
22. Sharples E.J. Novel applications of Erythropoietin / E.J. Sharples, C. Thiemermann, M. Yaqoob // Current Opinions in Pharmacology. – 2006. - №6. – Р. 184-189.
23. Soliz J. Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies / J. Soliz, V. Joseph, C. Soulage, C.Becskei, J.Vogel, et al. // J Physiol. – 2005. - № 568. – Р. 559-571.
24. Suckow M.A. The laboratory mouse / M.A. Suckow, Danneman P., Brayton C. – New York: CRC Press, 2001. – 176 p.
25. Wiesener M.S. Widespread hypoxia-inducible expression of Hif2alpha in distinct cell populations of different organs / M.S. Wiesener, J.S. Jürgensen, C. Rosenberger, C.K. Scholze, J.H. Hörstrup, C. Warnecke, et al. // FASEB J. – 2003. – № 17. – Р. 271-273
26. Wilber R.L. Effect of hypoxic "dose" on physiological responses and sea-level performance / R.L. Wilber, J. Stray-Gundersen, B.D. Levine // Med. Sci. Sports. Exerc. – 2007. - №39. – Р. 1590-1599.
27. Wright G.L. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemiareperfusion injury / G.L. Wright, P. Hanlon, K. Amin, C. Steenbergen, E. Murphy, M.O. Arcasoy // FASEB J. – 2004. - №18. – Р. 1031-1033.
28. Wu H. Inactivation of erythropoietin leads to defects in cardiac morphogenesis / .H Wu, SH. Lee, J. Gao, X. Liu and ML. Iruela-Arispe // Development. - 1999. - №126. Р. 3597-3605.
2. Федоров Н.А. Эритропоэтин / Н.А. Федоров, М.Г. Кахетемидзе. - М: Медицина, 1973. - 190 с.
3. Alvarez A. Role of vascular endothelial growth factor on erythropoietinrelated endothelial cell proliferation / A. Alvarez, M. Castilla, P. Gonzalez, D. Tan, A. Riesco, et al. // J. Am. Soc. Nephrol. – 1998. - № 9. – Р. 1998-2004.
4. Contaldo C. Human recombinant erythropoietin protects the striated muscle microcirculation of the dorsal skinfold from postischemic injury in mice / C. Contaldo, C. Meier, A. Elsherbiny, et al. // Am. J. Physiol. Heart. Circ. Physiol. – 2007. - №293. – Р. 274-283.
5. Gareau R. Exercise duration and serum erythropoietin level / R. Gareau, C. Caron, G.R. Brisson // Horm. Metab. Res. – 1991. - №23. – Р. 355.
6. Gassmann M. Non-erythroid functions of erythropoietin / M. Gassmann, K. Heinicke, J. Soliz and O.Ogunshola // Adv. Exp. Med. Biol. – 2003. - № 543. – Р. 323-330.
7. Grimm C. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration / C.Grimm, A.Wenzel, M.Groszer, H.Mayser, M.Seeliger, M.Samardzija, C. Bauer, M. Gassmann and C.Reme // Nat. Med. – 2002. – Jun. 8. – Р. 718-724.
8. Jelkmann W. Molecular biology of erythropoietin / W. Jelkmann // Intern. Med. – 2004. – №43. - 649-659.
9. Junk A.K. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury / AK.Junk, A.Mammis, SI. Savitz, M.Singh, S.Roth, S.Malhotra, PS. Rosenbaum, A.Cerami, M.Brines DM. Rosenbaum // Proc. Natl. Acad. Sci USA. - 2002. – Aug. 6: 99 (16). – Р. 10659-10664.
10. Levine B.D. "Living high-training low": effect of moderatealtitude acclimatization with low-altitude training on performance / B.D. Levine, J. Stray-Gundersen // J. Appl. Physiol. – 1997. - №83. – Р. 102-112.
11. Levine B.D. Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume / B.D. Levine, J. Stray-Gundersen // J. Appl. Physiol. – 2005. - №99. – Р. 2053-2055.
12. Lundby C. Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle / C. Lundby, Y. Hellsten, MB. Jensen, AS. Munch and H.Pilegaard // Journal Appl. Physiol. - 2008. - № 104. – Р. 1154-1160.
13. Marzo F. Erythropoietin in heart and vessels: focus on transcription and signalling pathways / F. Marzo, A. Lavorgna, G. Coluzzi, E. Santucci, F. Tarantino, T. Rio, E. Conti, C. Autore, L. Agati and F.Andreotti // Journal of Thrombosis and Thrombolysis. - 04/2008.- 26(3). – Р. 183-187.
14. Miskowiak K. Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration / K. Miskowiak, B. Inkster, S. Selvaraj, R. Wise, G. Goodwin, C. Harmer // Neuropsychopharmacology. – 2008. - № 33. – Р. 611-618.
15. Ninot G. Effects of recombinant human erythropoietin injections on physical self in endurance athletes / G. Ninot, P. Connes, C. Caillaud // J Sports Sci. – 2006. - №24. – Р. 383-391.
16. Paschos N. The Role of Erythropoietin as an Inhibitor of Tissue Ischemia / Nikolaos Paschos, Marios G. Lykissas and Alexandros E. Beris // International Journal of Biological Sciences. - 2008. - № 4(3). – Р. 161-168.
17. Porsolt R. D. Depression: а new animal model sensitive to antidepressant treatments / R. D. Porsolt, M. Le Pinchon, M. Jalfre // Nature. - 1977. - № 5604. - P. 730–732.
18. Ricci G. Effects of a mixed physical activity (biathlon) on haematologic parameters, red cell 2,3-DPG and creatine, serum erythropoietin, urinary enzymes and microalbumin / G. Ricci, M. Masotti, E. De Paoli, M. Vedovato, G. Zanotti // Eur. J. Haematol. – 1990. - №45. – Р. 178-179.
19. Schmidt W. Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level / W. Schmidt, K. Eckardt, A. Hilgendorf, S. Strauch, C. Bauer // Int. J. Sports. Med. – 1991. - №12. – Р. 457-461.
20. Schobersberger W. Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude / W. Schobersberger, P. Hobisch-Hagen, D. Fries, F. Wiedermann, J. Rieder-Scharinger, et al. // Immunobiology. – 2000. - №201. – Р. 611-620.
21. Schwandt H.J. Influence of prolonged physical exercise on the erythropoietin concentration in blood / H.J. Schwandt, B. Heyduck, H.C. Gunga, L. Rocker // J. Appl. Physiol. Occup. Physiol. - 1991. - №63. – Р. 463-466.
22. Sharples E.J. Novel applications of Erythropoietin / E.J. Sharples, C. Thiemermann, M. Yaqoob // Current Opinions in Pharmacology. – 2006. - №6. – Р. 184-189.
23. Soliz J. Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies / J. Soliz, V. Joseph, C. Soulage, C.Becskei, J.Vogel, et al. // J Physiol. – 2005. - № 568. – Р. 559-571.
24. Suckow M.A. The laboratory mouse / M.A. Suckow, Danneman P., Brayton C. – New York: CRC Press, 2001. – 176 p.
25. Wiesener M.S. Widespread hypoxia-inducible expression of Hif2alpha in distinct cell populations of different organs / M.S. Wiesener, J.S. Jürgensen, C. Rosenberger, C.K. Scholze, J.H. Hörstrup, C. Warnecke, et al. // FASEB J. – 2003. – № 17. – Р. 271-273
26. Wilber R.L. Effect of hypoxic "dose" on physiological responses and sea-level performance / R.L. Wilber, J. Stray-Gundersen, B.D. Levine // Med. Sci. Sports. Exerc. – 2007. - №39. – Р. 1590-1599.
27. Wright G.L. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemiareperfusion injury / G.L. Wright, P. Hanlon, K. Amin, C. Steenbergen, E. Murphy, M.O. Arcasoy // FASEB J. – 2004. - №18. – Р. 1031-1033.
28. Wu H. Inactivation of erythropoietin leads to defects in cardiac morphogenesis / .H Wu, SH. Lee, J. Gao, X. Liu and ML. Iruela-Arispe // Development. - 1999. - №126. Р. 3597-3605.